Apr 15, 2008 multidrugresistant acinetobacter baumannii is recognized to be among the most difficult antimicrobialresistant gramnegative bacilli to control and treat. Guide to the elimination of acinetobacter baumannii in long term care facilities, apic 2010 pdf antibiotic resistance threats in the united states, 20, centers for disease control and prevention pdf oregon hai website. Habitat and morphology of acinetobacter baumannii online. The aim of this study was to evaluate the susceptibilities of genotypically different a. Acinetobacter baumannii is a cause of healthcareassociated infections. Carbapenems, sulbactam, and colistin are the most effective antibiotics. These infections are strongly associated with the ability of pathogens to form biofilms on biotic and abiotic surfaces. Biofilm formation is mediated by csu pili, assembled via the archaic chaperoneusher pathway. Panantibioticresistant acinetobacter baumannii is one of the most troublesome pathogens, capable of colonizing medical devices by means of csu pili, an adhesive organelle that. In the intensive care setting, acinetobacter baumannii causes ventilatorassociated pneumonia and other nosocomial infections that are difficult to treat. Outer membrane protein, oma87 prevents acinetobacter baumannii infection iraj rasooli1,2,5 raziyeh abdolhamidi1 abolfazl jahangiri3 shakiba darvish alipour astaneh4 accepted.
Increased blaoxa23like prevalence in acinetobacter baumannii at a tertiary care center in lebanon 2007 20. Ribot em, fair ma, gautom r, cameron dn, hunter sb. Aug 23, 2019 trends in antimicrobial resistance help inform infection control efforts. Multidrugresistant acinetobacter baumannii clone, france. Acinetobacter baumannii published on dec 20 by american association of neurological surgeons. Acinetobacter baumannii bmc infectious diseases biomed central.
Participants were requested to fill in a short questionnaire with demographic data age, gender, source of isolation i. The respiratory tract, blood, pleural fluid, urinary tract, surgical wounds, cns, skin and eyes may be sites for infection or colonization. In addition to causing severe disease in hospitalized patients, a. Acinetobacter baumannii is an aerobic, nonlactose fermenting, oxidasenegative, gramnegative coccobacillus that is most commonly. Mar 14, 2010 acinetobacter baumannii is emerging infectious diseases resistant to several antibiotics early diagnosis and optimal treatment can reduce morbidity and mortali.
Multiple sequence types responsible for healthcare. In this retrospective analysis, patients 16 yearsold who received iv colistin or colistinsulbactam for the treatment of mdr a. The xray structure of the csuccsue chaperoneadhesin preassembly complex reveals the. Acinetobacter baumannii specifically targets moist tissues such as mucous membranes or areas of the skin that are exposed, either through accident or injury acinetobacter baumannii is found only rarely as part of the normal skin microflora, with one. Acinetobacter baumannii is an aerobic, nonfermentative, gramnegative, nonmotile, coccobacilli harboring a number of effective virulence factors. Concomitant contamination of air and environmental surfaces volume 37 issue 7 luis a. Carbapenemnonsusceptible acinetobacter baumannii, 8 us. However, there is no experimental evidence demonstrating that a. Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant. The treatment of acinetobacter baumannii infections is difficult. Nosocomial acinetobacter baumannii infections and changing. It can also colonize or live in a patient without causing infections or symptoms, especially in respiratory secretions sputum or open wounds.
Frequencies and incidence densities per 1,000 patientdays of esblproducing k. An alarming increase in the resistance rates of tigecycline and colistin among carbapenemaseproducing acinetobacter baumannii recovered from a greek hospital over a 3year period 2011 20 was investigated. Acinetobacter baumannii is an opportunistic bacterial pathogen primarily associated with hospitalacquired infections. Acinetobacter baumannii an overview sciencedirect topics. Recently, we described a situation in which carbapenemresistant a. Healthcare provider information sheet for acinetobacter. Acinetobacter is a complex genus of gramnegative bacteria that cause infections associated with significant morbidity and mortality. Acinetobacter is a genus of gramnegative bacteria belonging to the wider class of gammaproteobacteria.
Acinetobacter baumannii ab prevention solutions designed. Systematic search and quality assessment were performed to select eligible studies reporting one of the following outcomes. Isolates were collected prospectively between 01 20 and 05 20. Objective of this study was to investigate nosocomial a. Antibioticresistant infectious bacteria currently imply a high risk and therefore constitute a strong challenge when treating patients in hospital settings. Carbapenems, sulbactam and colistin seem to be the most effective antibiotics for treatment 3. It is a frequent cause of pneumonia and septicemia in immunocompromised patients. Acinetobacter baumannii, a nonfermenter gramnegative coccobacillus, was considered a lowcategory pathogen in the past, but has now emerged as a leading cause of hospital and communityacquired infections. We analyzed antimicrobial susceptibility of nonduplicate isolates in hospitalized patients not limited to hospitalacquired infections in the us bd insights research database. One study showed that capsular polysaccharides are involved. It rapidly acquires antibiotic resistance, leading to the spread of multidrugresistant strains impervious to nearly all antibiotic treatments 1 3. Increasing antimicrobial resistance among acinetobacter isolates has been documented, although definitions of multidrug resistance vary in the literature. Antimicrobial susceptibility of acinetobacter baumannii.
Pdf outbreak of ndm1producing acinetobacter baumannii. Acinetobacter pittii and acinetobacter nosocomialis among. We report the first outbreak of carbapenemresistant ndm1producing acinetobacter baumannii in europe, in a french intensivecare unit in january to may 20. Antibioticresistant acinetobacter baumannii increasing. Shimose, eriko masuda, maroun sfeir, ana berbel caban, maria x. An optimal therapy for the treatment of pneumonia caused by drugresistant acinetobacter baumannii remains unclear. While other species of the genus acinetobacter are often found in. Keywords abar4, acinetobacter baumannii, gc1, iran, tehran, tn2006, antibiotic resistance, carbapenem resistance, genomic island, global clone 1, oxa23, oxa72 a cinetobacter baumannii is a gramnegative opportunistic pathogen that causes a range of nosocomial infections. Acinetobacter species are oxidasenegative, exhibit twitching motility, and occur in pairs under magnification. Two case patients developed infections classified as community acquired under standard epidemiological definitions, but wgs revealed clonality, highlighting the risk of burn patients for earlyonset.
The incidence of multidrugresistant acinetobacter baumannii mdr a. It typically infects people inside a healthcare facility doctors refer to these as nosocomial infections. Of the 6 airclinical isolate pairs available, 4 pairs were closely related according to reppcr. It has excellent colonizing potential, and contact transmission is a big challenge intermittent as well as endemic outbreaks. Acinetobacter baumannii strain m2 produces type iv pili. Acinetobacter baumannii is one of the most clinically significant multidrugresistant organisms in intensive care units icus worldwide 1, 2, with the hospital environment serving as a major reservoir 3 5. This study aims to compare various antimicrobial strategies and to determine the most effective therapy for pneumonia using a network metaanalysis. Acinetobacter baumannii is a gramnegative, opportunistic pathogen. Acinetobacter baumannii is an increasingly problematic hospitalassociated opportunistic pathogen. Acinetobacter baumannii is a bacterium that can cause a range of diseases.
Molecular identification of tigecycline and colistin. December application of bacteriophagecontaining aerosol against nosocomial transmission of carbapenemresistant acinetobacter baumannii in an intensive care unit yuhuai ho 0 1 chunchieh tseng 1 lihshinn wang 0 1 yiting chen 1 guanjin ho 1 teng yi lin 1 lingyi wang 1 likuang chen 1 0 division of infectious diseases, department of internal medicine, buddhist tzu chi general hospital. Contamination of ambient air with acinetobacter baumannii. Acinetobacter baumannii maintains its virulence after long. Acinetobacter baumannii, a nonmotile, glucose non fermentative, oxidase negative, encapsulated, gramnegative coccobacillus, has recently gained importance because of its increasing resistance to the available antibiotics. While there are many types or species of acinetobacter, and all can cause human disease, acinetobacter baumannii boemaaneeie accounts for about 80% of reported infections. Acinetobacter baumannii resistance trends in children in. It resists many classes of antibiotics by virtue of chromosomemediated genetic elements on. Acinetobacter species are oxidasenegative, exhibit twitching motility, and occur in pairs under magnification they are important soil organisms, where they contribute to the mineralization of, for example, aromatic compounds. Acinetobacter baumannii, acinetobacter pittii, acinetobacter nosocomialis, and acinetobacter calcoaceticus are grouped as the acinetobacter calcoaceticusbaumannii complex abc as they are mutually closely related and are difficult to be distinguished from each other by phenotypic properties. Between and, acinetobacter species were the only forms provided by the authors are available with the full text of this article at go to. Acinetobacter baumannii is an opportunistic pathogen that is a source of nosocomial infections, mostly pneumonia.
Acinetobacter is a gramnegative bacterium commonly found in soil and water. The major compound, fimsbactin a, was isolated from low. Trends in antimicrobial resistance help inform infection control efforts. Genome sequence analysis of an extensively drugresistant. Under the microscope, it looks halfway between a rod and a ball. To compare clinical and microbiological efficacy of colistin and colistinsulbactam for the treatment of multidrugresistant mdr acinetobacter baumannii vap in intensive care units icus. Acinetobacter baumannii has emerged as a medically important pathogen because of the increasing number of infections produced by this organism over the preceding three decades and the global spread of strains with resistance to multiple antibiotic classes. Comparison of colistin and colistinsulbactam for the. Characterization of these species and of particular strains is a priority for the establishment of diagnostic tests and preventive procedures. Umgang mit patienten mit multiresistentem acinetobacter baumannii.
The recent increase in incidence, largely associated with infected combat troops returning from conflict zones, coupled with a dramatic increase in the incidence of multidrugresistant mdr strains, has significantly raised the profile of this emerging opportunistic pathogen. Acinetobacter baumannii is an important nosocomial pathogen that causes a variety of diseases, such as pneumonia, skin and soft tissue infections, meningitis and. Defining genephenotype relationships in acinetobacter. We examined trends in resistance for enterobacteriaceae and acinetobacter spp. Rates of infection with hospitalacquired acinetobacter baumannii have exploded over the past decade due to our inability to limit persistence and effectively treat disease. Drug treatment for multidrugresistant acinetobacter. A centers for disease control and prevention cdc report, antimicrobial resistance threats in. Acinetobacter baumannii is emerging infectious diseases resistant to several antibiotics early diagnosis and optimal treatment can reduce morbidity and mortali.
It can be an opportunistic pathogen in humans, affecting people with compromised immune systems, and is becoming increasingly important as a hospitalderived infection. While there are many species of acinetobacter that can cause human disease, acinetobacter baumannii a. Following their traditional role, the two component systems tcss present in a. Burden of multidrugresistant acinetobacter baumannii. Department of virology, bacteriology infection control, parasitology mycology, assistance publique hopitaux. In spite of its clinical relevance, until recently, there have been few studies. Acinetobacter baumannii is a notorious pathogen in health care settings around the world, primarily due to high resistance to antibiotics. Systematic search and quality assessment were performed to select eligible studies reporting one of the following. Outer membrane protein, oma87 prevents acinetobacter. Acinetobacter positive patients had their ambient air tested for up to 10 consecutive days.
Pdf acinetobacter baumannii, a nonmotile, glucose non fermentative, oxidase. Acinetobacter baumannii resistance trends in children in the. It has excellent colonizing potential, and contact transmission is a. Jul 01, 20 acinetobacter baumannii, acinetobacter pittii, acinetobacter nosocomialis, and acinetobacter calcoaceticus are grouped as the acinetobacter calcoaceticus baumannii complex abc as they are mutually closely related and are difficult to be distinguished from each other by phenotypic properties. Acinetobacter baumannii is an increasing cause for multidrugresistant nosocomial infections, with the potential to rival mrsa. Acinetobacter baumannii is an aerobic, nonlactose fermenting, oxidasenegative, gramnegative coccobacillus that is most commonly found associated with healthcare environments.
In spite of its clinical relevance, until recently, there have been few studies addressing the factors that contribute to the pathogenesis. Sulbactam shows high efficacy against acinetobacter species in vitro and in vivo 4 6. Acinetobacter baumannii can cause infections in the blood, urinary tract, and lungs pneumonia, or in wounds in other parts of the body. Trends in resistant enterobacteriaceae and acinetobacter. Dec 07, 2014 infections due to resistant acinetobacter baumannii isolates cause difficulties in treatment. Acinetobacter baumanniia leading cause of nosocomial infectionshas a remarkable capacity to persist in hospital environments and medical devices due to its ability to form biofilms. Pdf outbreak of ndm1producing acinetobacter baumannii in. Treatment options for infections caused by carbapenemresistant. The antimicrobial resistance profiles and carbapenemase gene content were determined for a collection of colistin andor tigecyclineresistant carbapenemaseproducing a. Contamination of ambient air with acinetobacter baumannii on.
The relevance of acinetobacter baumannii as a problematic microorganism in inpatient. Acinetobacter baumannii is an increasingly worrying organism in the healthcare setting, due to its multidrug resistance and persistence. Jane buckle phd, rn, in clinical aromatherapy third edition, 2015. Antimicrobial susceptibilities of clinical acinetobacter. Acinetobacter isolates often demonstrate resistance to multiple classes of antimicrobial drugs, leading to treatment challenges. May 22, 2018 nosocomial infections and infections of indwelling devices are major healthcare problems worldwide. Acinetobacter baumannii is the most common human pathogen of the genus, and it is well known for its ability to resist desiccation and persist in the environment, which facilitates transmission in healthcare settings. Accumulation of antibiotic resistance genes in carbapenem. Multidrugresistant acinetobacter baumannii mdrab causes wound and bloodstream infections as well as ventilatorassociated pneumonia. Acinetobacter spp aspectos microbiologicos, clinicos y.
Acinetobacter baumannii is a typically short, almost round, rodshaped coccobacillus gramnegative bacterium. We report a cluster of highly resistant acinetobacter baumannii that occurred in a burn icu over 5 months and then spread to a separate icu. Application of bacteriophagecontaining aerosol against. The air was acinetobacter positive for an average of 21% of the days. December application of bacteriophagecontaining aerosol against nosocomial transmission of carbapenemresistant acinetobacter baumannii in an intensive care unit yuhuai ho 0 1 chunchieh tseng 1 lihshinn wang 0 1 yiting chen 1 guanjin ho 1 teng yi lin 1 lingyi wang 1 likuang chen 1 0 division of infectious diseases, department of internal medicine, buddhist tzu chi general hospital and. The bacterium acinetobacter baumannii is a recognized cause of healthcareassociated illness, including pneumonia, bacteremia, and urinary tract infections utis. Acinetobacter baumannii ein krankenhauskeim mit beunruhigendem entwicklungspotenzial. Prolonged hospitalisation, immunocompromised patients and excessive antibiotic exposure all contribute to increasing the risk of a. Structural basis for acinetobacter baumannii biofilm. Structure and biosynthesis of fimsbactins af, siderophores. Spychala, timothy cleary, nicholas namias, daniel h. Infections due to resistant acinetobacter baumannii isolates cause difficulties in treatment.
30 740 804 851 1223 1126 434 1406 1047 470 406 319 1256 793 1097 655 620 867 1117 1187 676 945 393 1194 272 481 1111 594 1314